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Papules and nodules are categorized as primary lesions, which are the initial manifestations of skin changes or conditions. Primary lesions are abnormal structural changes in the skin that arise due to a variety of factors, including inflammation, infection, or other underlying processes.

Papules are small, raised, solid bumps on the skin that can vary in size and color, while nodules are larger, raised solid lesions, often deeper in the dermis. Both forms are considered primary because they occur directly as a result of the skin's response to irritation, infection, or other alterations, rather than as a consequence of another lesion or condition.

In contrast, secondary lesions occur as a result of the evolution of primary lesions or other skin conditions. Infectious lesions pertain specifically to those caused by infectious agents, and neoplastic lesions relate to growths that may be benign or malignant. Neither infectious nor neoplastic classifications adequately encompass the characteristics that define papules and nodules, which is why primary lesions is the most accurate classification for these types of skin abnormalities.