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A key sign of malignant melanoma includes:

  1. Development of nodules

  2. Change in mole color

  3. Scab formation

  4. Increased itching

The correct answer is: Change in mole color

The development of malignant melanoma often includes changes in the color of existing moles. This change can manifest as a darkening of the mole, uneven coloration with multiple shades, or the appearance of a new, irregularly colored mole. Such changes are significant because they may indicate abnormal cell behavior, which could lead to cancer. Recognizing these color variations is crucial for early detection, as melanoma is a particularly aggressive form of skin cancer and early intervention can drastically improve outcomes. While the presence of nodules, scab formation, and increased itching are also signs that can be associated with skin issues, they are not as definitive as changes in color when it comes to identifying malignant melanoma. Conditions like benign moles or other skin ailments can exhibit these symptoms without indicating melanoma, making color change a more critical sign for diagnosis.